PUBLICATIONS

| Selected |

Thalamic integration of basal ganglia and cerebellar circuits during motor learning

Roth RH, Muniak MA, Huang CJ, Hwang FJ, Sun Y, Min C, Mao T, Ding JB.

bioRxiv: doi.org/10.1101/2024.10.31.621388

Cortico-basal ganglia plasticity in motor learning

Roth RH†, Ding JB†. (2025)

Neuron, 112 (15): 2486-2502. doi.org/10.1016/j.neuron.2024.06.014

Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons

Hwang FJ*, Roth RH*, Wu YW, Sun Y, Kwon DK, Liu Y, Ding JB. (2022)

Neuron, 110 (17): 2790-2801. doi.org/10.1016/j.neuron.2022.06.006

Cortical Synaptic AMPA Receptor Plasticity During Motor Learning

Roth RH, Cudmore RH, Tan HL, Hong I, Zhang Y, Huganir RL. (2020)

Neuron, 105 (5): 895-908. doi.org/10.1016/j.neuron.2019.12.005

| All Publications |

Primary Research

2025 | Thalamic integration of basal ganglia and cerebellar circuits during motor learning. Roth RH, Muniak MA, Huang CJ, Hwang FJ, Sun Y, Min C, Mao T, Ding JB.

bioRχiv - doi.org/10.1101/2024.10.31.621388

2025 | Remodelling of corticostriatal axonal boutons during motor learning. Sheng M, Lu D, Roth RH, Hwang FJ, Sheng K, and Ding JB.

Nature, 646. DOI: 10.1038/s41586-025-09336-w

2024 | Achieving optical transparency in live animals with absorbing molecules. Ou Z, Duh YS, Rommelfanger NJ, Keck CHC, Jiang S, Brinson Jr K, Zhao S, Schmidt EL, Wu X, Yang F, Cai B, Cui H, Qi W, Wu S, Tantry A, Roth RH, Ding JB, Chen X, Kaltschmidt JA, Brongersma ML, Hong G.

Science, 385 (6713). DOI: 10.1126/science.adm6869

2024 | Oligodendrocytes and myelin limit neuronal plasticity in visual cortex. Xin W, Kaneko M, Roth RH, Zhang A, Nocera S, Ding JB, Stryker MP, Chan JR.

Nature, 633: 856-863. doi.org/10.1038/s41586-024-07853-8

bioRχiv - doi.org/10.1101/2023.09.29.560231

2024 | A fast and responsive voltage indicator with enhanced sensitivity for unitary synaptic events. Hao YA, Lee S, Roth RH, Natale S, Gomez L, Taxidis J, O’Neill PS, Villette V, Bradley J, Wang Z, Jiang D, Zhang G, Sheng M, Lu D, Boyden E, Delvendahl I, Golshani P, Wernig M, Feldman DE, Ji N, Ding JB, Südhof TC, Clandinin TR, Lin MZ.

Neuron, 112 (15). DOI: 10.1016/j.neuron.2024.08.019

2024 | Stimulus-dependent synaptic plasticity underlies neuronal circuitry refinement in the mouse primary visual cortex. Lopez-Ortega E, Choi JY, Hong I, Roth RH, Cudmore RH, Huganir RL.

Cell Reports, 43 (4). DOI: 10.1016/j.celrep.2024.113966

2023 | A positively tuned voltage indicator for extended electrical recordings in the brain. Evans SW, Shi DQ, Chavarha M, Plitt MH, Taxidis J, Madruga B, Fan JL, Hwang FJ, van Keulen SC, Suomivuori CM, Pang MM, Su S, Lee S, Hao YA, Zhang G, Jiang D, Pradhan L, Roth RH, Liu Y, Dorian CC, Reese AL, Negrean A, Losonczy A, Makinson CD, Wang S, Clandinin TR, Dror RO, Ding JB, Ji N, Golshani P, Giocomo LM, Bi GQ, Lin MZ.

Nature Methods, 20. DOI: 10.1038/s41592-023-01913-z

2022 | Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons. Hwang FJ*, Roth RH*, Wu YW, Sun Y, Kwon DK, Liu Y, Ding JB.

Neuron, 110 (17). DOI: 10.1016/j.neuron.2022.06.006

2021 | Visualizing synaptic plasticity in vivo by largescale imaging of endogenous AMPA receptors. Graves AR*, Roth RH*, Tan HL*, Zhu Q*, Bygrave A*, Lopez-Ortega E*, Hong I, Spiegel A, Johnson RC, Vogelstein J, Tward D, Miller MI, Huganir RL.

eLife, 10. DOI: 10.7554/eLife.66809

2021 | AMPA receptors exist in tunable mobile and immobile synaptic fractions in vivo. Chen H, Roth RH, Lopez-Ortega E, Tan HL, Huganir RL.

eNeuro, 8 (3). DOI: 10.1523/ENEURO.0015-21.2021

2021 | An Optimized CRISPR/Cas9 Approach for Precise Genome Editing in Neurons. Fang H, Bygrave AM, Roth RH, Johnson RC, Huganir RL.

eLife, 10. DOI: 10.7554/eLife.65202

2020 | Cortical Synaptic AMPA Receptor Plasticity During Motor Learning. Roth RH, Cudmore RH, Tan HL, Hong I, Zhang Y, Huganir RL.

Neuron, 105 (5). DOI: 10.1016/j.neuron.2019.12.005

2020 | An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice. Zhang JF, Liu B, Hong I, Mo A, Roth RH, Tenner B, Lin W, Zhang JZ, Molina RS, Drobizhev M, Hughes TE, Tian L, Huganir RL, Mehta S, Zhang J.

Nature Chemical Biology, 17. DOI: 10.1038/s41589-02000660-y

2018 | Singlefluorophore biosensors for sensitive and multiplexed detection of signalling activities. Mehta S*, Zhang Y*, Roth RH*, Zhang JF, Mo A, Tenner B, Huganir RL, Zhang J.

Nature Cell Biology, 20 (10). DOI: 10.1038/s41556-018-0200-6

2020 | Lamina-specific AMPA receptor dynamics following visual deprivation in vivo. Tan HL, Roth RH, Graves AR, Cudmore RH, Huganir RL.

eLife, 9. DOI: 10.7554/eLife.52420

2017 | Homer1a drives homeostatic scaling-down of excitatory synapses during sleep. Diering GH, Nirujogi RS*, Roth RH*, Worley PF, Pandey A, Huganir RL.

Science, 355 (6324). DOI: 10.1126/science.aai8355

2016 | Synaptic Organization of the Neuronal Circuits of the Claustrum. Kim J, Matney CJ, Roth RH, Brown SP.

Journal of Neuroscience, 36 (3). DOI: 10.1523/JNEUROSCI.3643-15.2016

Reviews and Commentaries

2024 | Cortico-basal ganglia plasticity in motor learning. Roth RH†, Ding JB†.

Neuron, 112 (15). DOI: 10.1016/j.neuron.2024.06.014

2020 | From Neurons to Cognition: Technologies for Precise Recording of Neural Activity Underlying Behavior. Roth RH, Ding JB.

BME Frontiers, 2020. DOI: 10.34133/2020/7190517

2017 | Dynamic imaging of AMPA receptor trafficking in vitro and in vivo. Roth RH*, Zhang Y*, Huganir RL.

Curr Opin Neurobiology, 45. DOI: 10.1016/j.conb.2017.03.008

†corresponding *equal contribution

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